How to keep a hemorrhoid from bursting open and leaking puss?
I have an infected hemorrhoid that leaks puss. What is the best medicine?

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Going to a doctor, probably, to make sure you don’t get a worse infection into your bloodstream.
Otherwise you can try smearing it with an antibiotic ointment after squeezing the pus out. However, this runs the risk of the infection going deeper and then having to have something more serious done.